A g e n d a
Day 1: Wednesday May 28th
Arrival/Registration
1:00-5:00 pm
Redford Conference Center
Ramiro Garzon, MD (Huntsman Cancer Institute at U of U)
5:00-5:25 pm
Introduction / Welcome
Craig Sandoval (Urban Indian Center of Salt Lake)
5:25-5:30 pm
Native American Blessing
“Targeting malignant stem cells to improve AML therapy"
Craig Jordan, PhD (University of Colorado)
5:30-6:25 pm
Keynote Speaker
Welcome Reception/Dinner
6:30-8:00 pm
Rehearsal Hall
8:00-10:00 pm
Native American Music / Elder Teachings
Wild Salmon and Craig Sandoval
Rehearsal Hall Deck
Day 2: Thursday May 29th
Session 1: Epigenetics / Signaling
8:00-10:30am
Chairs: Jeff Tyner (OHSU) and Birgit Knoechel, MD, PhD (HCI)
Redford Conference Center
“Single-cell Genomics in Normal and Malignant Hematopoiesis”
8:00-8:25 am
Ted Braun (Oregon Health and Science University)
Srinivas Ramachandran (CU Anschutz Medical Campus)
8:25-8:50 am
“Reconstructing Genome Regulation”
Craig Forester (CU Anschutz Medical Campus)
8:50-9:15 am
“A Novel Mutation in Taspase1 Leads to Marrow Failure Through Aberrant RNA Polymerase II Targeting”
“Resetting the Epigenetic Memory of AML Cells”
9:15-9:40 am
Ani Deshpande (Sanford Prebys)
Jevon Cutler (Pediatrics; Oregon Health and Science University)
9:40-10:05 am
“Mechanisms of Menin Inhibitor Efficacy and Resistance in Leukemia”
Luis Batista (Washington University in St. Louis)
10:05-10:30 am
"Genomic instability – a unifying feature of bone marrow failure syndromes"
1:05-4:00 pm
Lunch
Rehearsal Hall
1:00-3:30 pm
Break Out Session
UC / HCI / OHSU Leaders Meeting
Breakfast
7:00-8:00 am
Rehearsal Hall
Tea and Coffee Break
10:30-11:00 am
Redford Conference Center
Chairs: Dan Couriel, MD (U of U) and Sagar Patel, MD (HCI)
Session 2: Cellular Therapy
11:00-1:05 pm
M. Eric Kohler (CU Anschutz Medical Campus; Children's Hospital Colorado)
Redford Conference Center
11:00-11:25 am
“Novel Approaches to Improve CAR T Cell Therapy in AML”
Catherine Bollard (Children's National Hospital; The George Washington University)
11:25-11:50 am
“T cell Therapies for Blood Cancers – Beyond Conventional CAR-T”
Lawrence Fong (Fred Hutchinson Cancer Center)
11:50-12:15 pm
“Identifying Mechanisms of Resistance to BCMA CAR T cells”
Dr Jens Lohr (Huntsman Cancer Institute at U of U)
12:15-12:40 pm
“Liquid Biopsy and Next-Gen Immunotherapies”
Matt Witkowski (CU Anschutz Medical Campus)
12:40-1:05 pm
“Inhibiting Free Fatty Acid Transport to Improve CAR-T Cell Therapy of Relapsed B-cell Acute Lymphoblastic Leukemia”
Screening Room
Break Out Session-MPN/AML
1:45-3:45 pm
Sponsored by MPN Research Foundation
Redford Conference Center
Chairs: Anna Beaudin (U of U) + Steve Sykes (WashU)
Session 3: Metabolism
4:00-6:30 pm
Redford Conference Center
Shannon Elf (University of Utah)
“Calcium-Mediated Metabolic Reprogramming Drives MPN disease Progression”
4:00-4:25 pm
4:25-4:50 pm
Courtney Jones (Cincinnati Children's Hospital)
“Targeting Protein Glutathionylation in Acute Myeloid Leukemia”
“More than Just Food: Delineating the Impact of Obesity on B-ALL Progression and Responses to Immunotherapies”
4:50-5:15 pm
Curtis J. Henry (The University of Colorado AMC; The University of Colorado Cancer Center)
Eric Pietras (CU Anschutz Medical Campus)
5:15-5:40 pm
“Metabolic Control of HSPC Expansion in Clonal Hematopoiesis”
“Nicotinamide Supplementation Leads to Metabolic Reprogramming of SF3B1 Mutant Stem Cells”
5:40-6:05 pm
Maria Amaya (CU Anschutz Medical Campus)
“Predicting Responses to Venetoclax in AML: How To and Why It Matters”
6:05-6:30 pm
Daniel A. Pollyea (The University of Colorado)
Redford Conference Center
7:30-8:30 pm
Barbecue Buffet
Rehearsal Hall Deck
Poster Session / Cocktail Hour
6:30-7:30pm
Sponsored by Leukemia & Lymphoma Society
8:00-11:00 pm
Live Music and Dancing
Crazy Coyote
Rehearsal Hall
Day 3: Friday May 30th
Breakfast
7:00-8:00 am
Session 4: Microenvironment / Inflammation
Rehearsal Hall
8:00-10:30am
Chair: Eric Pietras (UC) and Katherine King, PhD (Baylor)
Redford Conference Center
Konstantinos Kokkaliaris (Institute of Pathology, University Hospital Frankfurt)
8:00-8:25 am
“Remodeling of Bone Marrow Hematopoietic Microenvironment(s) Following Acute Stress”
Dr Anupriya Agarwal (Oregon Health and Science University)
8:25-8:50 am
“Inflammatory Microenvironment: Driver of Leukemia Initiation and Progression”
"T Cell States at Diagnosis Predict Chemotherapy Response in Acute Myeloid Leukemia"
8:50-9:15 am
Francesca Ferraro, MD, PhD (Washington University in St. Louis)
Rebekka Schneider (RWTH Aachen University Hospital)
9:15-9:40 am
“Unraveling Fibrosis in Myeloproliferative Neoplasms”
Mick Milsom (Heidelberg Institute for Stem Cell Technology and Experimental Medicine)
9:40-10:05 am
"Intrinsic and Extrinsic Programming of Hematopoietic Stem Cells During Aging"
Meenakshi Banerjee, PhD (Huntsman Cancer Institute at Uof U)
10:05-10:30 am
“Preserving Stemness:Targeting Interferon-Sensitive Genes to Mitigate Inflammatory Stress”
Tea and Coffee Break
10:30-11:00 am
Redford Conference Center
Session 5: Heme-Systems Interactions
11:00-1:05 pm
Chair: Melissa Wong (OHSU) and Len Zon, PhD (Boston Children's)
Redford Conference Center
11:00-11:25 am
Olga Guryanova (University of Florida)
“Clonal Hematopoiesis in Non-Hematologic Tissue Dysfunction”
Afaf Osman (Huntsman Cancer Institute at U of U)
11:25-11:50 am
“Clonal Hematopoiesis and Germline Predisposition in High-Risk Leukemia Pedigrees”
Katherine King (Baylor College of Medicine)
11:50-12:15 pm
“Mutation Specific Effects of Clonal Hematopoiesis on Alzheimer’s Disease Pathogenesis”
Matt Rodina (Huntsman Cancer Institute at U of U)
12:15-12:40 pm
“Interferon Response Elements in Thrombosis and Hemostasis”
Len Zon (Boston Children's Hospital)
12:40-1:05 pm
“Stem Cell Clonality and the Niche”
Rehearsal Hall
1:05-4:00 pm
1:05-4:00 pm
Lunch
Special Activites
Guided Hike, Scenic Lift Ride, Ziptour, Silversmithing and Journal Making
Sign up online for more details. Spots are limited!
Session 6: Challenges in Heme Malignancies
4:00-6:30 pm
Chairs: Ramiro Garzon, MD (HCI) + Dr Michael Pulsipher (HCI/Primary Children's)
Redford Conference Center
Ami Patel (University of Utah)
4:00-4:25 pm
“Challenges for New Drug Development in Oncology”
“MEK Inhibition in CMML"
4:25-4:50 pm
Ronan Swords, MD, PhD (Oregon Health and Science University)
4:50-5:15 pm
Curtis Lachowiez (Oregon Health and Science University)
"The Impact of AML Differentiation State and Genotype on Therapeutic Decision-Making in AML"
Nicole Kucine (Weill Cornell Medicine)
5:15-5:40 pm
“Myeloproliferative Neoplasms in Children, Adolescents, and Young Adults”
Ulrich Steidl, MD, PhD (Albert Einstein College of Medicine – Montefiore Medicine)
5:40-6:05 pm
"Understanding and Targeting Transcriptional Noise"
Uma Borate (The Ohio State University)
6:05-6:30 pm
“CHIP/CCUS: Unmet Need, Current Detection, and Clinical Practice”
Sponsored by The Morgan Adams Foundation and the WillStrong Leukemia Program
Panel Q+A
6:30-6:55 pm
Redford Conference Center
Tree Room Resturant
10:00-11:00 pm
Seated Dinner
7:00-9:30 pm
Campfire / Smores
Rehearsal Hall Deck
The Howlin’ Tomcats
Live Music
10:00-1:00am
The Owl Bar
Day 4: Saturday May 31st
Redford Conference Center
8:00-10:00 am
9:00-11:00am
Breakfast
Film Screening and Director Q+A
Screening Room
Silent Fallout directed by Hideaki Ito
11:00 am
Depature